IC: Vampire: The Masquerade SANCTUARY
That sounds like a pretty cool idea for a game, to me. If it's a small city, there probably aren't very many vampires in it, or if there are, the competition for turf/feeding rights would get pretty intense. Either way, you could do some interesting stuff with it.
You might get more bites with the 20th anniversary edition, but I'm cool with taking it old-school, myself.